What Is The Difference Between The First And Second Dose of The COVID-19 mRNA Vaccine?

Pfizer-BioNTech, and Moderna produced the first 2 COVID-19 vaccines, which employ messenger RNA (mRNA) to stimulate the recipient’s body to generate the coronavirus hallmark spike protein. Hence, when the coronavirus (SARS-CoV-2) enters the body, the immune system is able to identify the virus and create antibodies to resist it. Both of these mRNA vaccines require two doses to guarantee adequate immunisation coverage and to protect recipients from coronavirus.


Earlier studies demonstrated that the Pfizer-BioNTech and Modern vaccines generated a relatively weakTrusted Source of immunological response when provided in a single dosage. With second dosage, on the other hand, it elicited a higher immunological response. Based on a comprehensive review of safety and efficacy data from large-scale clinical studies, the FDA has determined that these mRNA vaccines require two doses.


In general, the first dose is administered as priming, to stimulate and prepare your immune system. The immune system is designed to expose to the spike protein of coronavirus and allows it to elicit a minor immunological response before the second dose. This procedure requires time to develop properly, followed by the second dose to enhance the immunity against coronavirus, assuring a longer period of protection.


It is indeed vital not to obtain your second dosage too soon, as this may reduce the efficacy of the vaccine. The Trusted Source at the Centers for Disease Control and Prevention (CDC) has also authorised the appropriate timeframe for each of these mRNA vaccines to achieve their best vaccination benefits. The Pfizer-BioNTech vaccine is administered in two doses, 21 days apart. The Moderna vaccination is administered in two doses, 28 days apart. The Pfizer-BioNTech vaccine was 95 percent effective after two doses, while the Moderna vaccine was 94.1 percent effective after two doses, preventing those who received the immunisation from contracting COVID-19. Until today, these mRNA vaccines still remain as one of the most promising vaccine types (jenis vaksin covid 19) globally.


What If I Unable To Get The Second Dose of mRNA Vaccine In Time?

In this case, the CDC Trusted Source suggests getting your second dosage as close to the needed interval as feasible. Many people are anxious about what will happen if the second dosage of immunisation is not acquired within the specified timeframes. The CDC Trusted Source offers advice on this as the second dose can be administered at the highest limit 6 weeks (42 days) following the first dose. If the second dosage is postponed longer than this time frame, the effectiveness of immunization may become unpredictable. Therefore, if feasible, attempt to plan your second dosage session on the same day as you receive the first dose.



As the immune response to the first dose of mRNA COVID-19 vaccines seems to be limited, such as those made by Pfizer-BioNTech and Moderna. A second dosage is required to aid in the reinforcement of this immunological response. However, the consequences of switching vaccinations are yet to be known, further studies are needed.


Make sure to keep your immunisation record card while you obtain your COVID-19 vaccination. This ensures that you know which vaccination you received and when you should plan your second dose.


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